topotecan sustained-release episcleral plaque

{
  "id": "MLC-T-ONC-017269",
  "term": "topotecan sustained-release episcleral plaque",
  "field": "Oncology and biomedicine",
  "definition": "An episcleral plaque containing sustained-release (SR) topotecan, a semisynthetic derivative of camptothecin and a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminate, with potential antineoplastic activity. Upon local application of the topotecan SR episcleral plaque to the eye, topotecan is released in a sustained manner and inhibits topoisomerase I activity by stabilizing the topoisomerase I-DNA covalent complexes during S phase of cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. The episcleral plaque allows for local delivery of topotecan for the potential treatment of retinoblastoma.",
  "synonyms": [
    "episcleral topotecan",
    "transscleral topotecan",
    "topotecan SR episcleral plaque",
    "sustained-release topotecan episcleral plaque",
    "SR topotecan episcleral plaque",
    "sustained-release episcleral topotecan"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/topotecan-sustained-release-episcleral-plaque/"
}