liposomal topotecan hydrochloride

{
  "id": "MLC-T-ONC-014832",
  "term": "liposomal topotecan hydrochloride",
  "field": "Oncology and biomedicine",
  "definition": "The hydrochloride salt of a semisynthetic derivative of camptothecin mixed with sphingomyelin/cholesterol and sonicated to form small unilamellar vesicles containing topotecan, with potential antineoplastic activity. Liposomal opotecan hydrochloride mediates efficient drug delivery of topotecan into the cytosol from the endosome compartment. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery.",
  "synonyms": [
    "topotecan hydrochloride liposomes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/liposomal-topotecan-hydrochloride/"
}