irinotecan sucrosofate

{
  "id": "MLC-T-ONC-004511",
  "term": "irinotecan sucrosofate",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A form of the anticancer drug irinotecan hydrochloride that is contained inside very tiny, fat-like particles and is used with other drugs to treat adults with pancreatic cancer that has spread to other parts of the body. It is used in patients whose cancer has not been treated with other anticancer therapy or has gotten worse after treatment with gemcitabine hydrochloride. It is also being studied in the treatment of other types of cancer. Irinotecan sucrosofate may have fewer side effects and work better than other forms of irinotecan hydrochloride. Irinotecan sucrosofate blocks a certain enzyme needed for cell division and DNA repair, and it may kill cancer cells. It is a type of topoisomerase inhibitor and a type of camptothecin analog. Also called Onivyde and PEP02.",
    "A liposomal dispersion formulated with the semisynthetic camptothecin analogue irinotecan, provided as the hydrochloride trihydrate form, which is encapsulated and entrapped within liposomes in a gelated or precipitated state as the irinotecan sucrose octasulfate (sucrosulfate) salt form, with potential antineoplastic activity. Upon administration of the liposomes containing irinotecan sucrosulfate, irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. During the S-phase, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Liposome encapsulation of this agent promotes efficient drug delivery into the cytosol from the endosome compartment of the cell, extends the circulation of irinotecan, and prolongs the duration of active therapy at the site of tumor to inhibit tumor growth."
  ],
  "synonyms": [
    "Onivyde",
    "PEP02",
    "irinotecan liposome",
    "nal-IRI",
    "nanoliposomal irinotecan",
    "nanoparticle liposome formulation of irinotecan",
    "irinotecan hydrochloride as sucrosulfate salt form liposomal formulation",
    "nanoliposomal irinotecan as sucrosofate",
    "irinotecan sucrosofate-containing pegylated liposomal formulation",
    "irinotecan sucrosofate liposome"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/irinotecan-sucrosofate/"
}