Irinotecan-eluting beads

{
  "id": "MLC-T-ONC-014576",
  "term": "Irinotecan-eluting beads",
  "field": "Oncology and biomedicine",
  "definition": "Microporous hydrospheres of polyvinylalcohol (PVA) impregnated with irinotecan with potential antineoplastic activity. In transarterial chemoembolization (TACE), irinotecan-eluting beads are administered into blood vessels that feed the tumor, occluding tumor blood vessels and inducing ischemic tumor necrosis while simultaneously delivering high-dose chemotherapy locally. Irinotecan, a semisynthetic derivative of camptothecin, inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death.",
  "synonyms": [
    "irinotecan hydrochloride drug-eluting beads"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/irinotecan-eluting-beads/"
}