Topotecan hydrochloride

{
  "id": "MLC-T-ONC-008764",
  "term": "Topotecan hydrochloride",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used alone or with other drugs to treat certain types of ovarian cancer, small cell lung cancer, and cervical cancer. It is also being studied in the treatment of other types of cancer. Topotecan hydrochloride blocks a certain enzyme needed for cell division and DNA repair, and it may kill cancer cells. It is a type of topoisomerase inhibitor and a type of camptothecin analog. Also called Hycamtin.",
    "The hydrochloride salt of a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata."
  ],
  "synonyms": [
    "Hycamtin",
    "topotecan hydrochloride (oral)",
    "hycamptamine",
    "topotecan HCl"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/topotecan-hydrochloride/"
}