anti-B7-H4/TOP1i antibody-drug conjugate GSK5733584

{
  "id": "MLC-T-ONC-010152",
  "term": "anti-B7-H4/TOP1i antibody-drug conjugate GSK5733584",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate (ADC) composed of a humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against B7-H4 (V-set domain-containing T-cell activation inhibitor 1; VTCN1; B7x; B7S1) linked, via a protease-cleavable linker, to a topoisomerase-1 inhibitor (TOP1i; TOP-Ii), with potential antineoplastic activity. Upon administration of anti-B7-H4/ TOP1i ADC GSK5733584, the anti-B7-H4 monoclonal antibody moiety targets and binds to B7-H4 expressed on tumor cells. Upon binding and internalization, the TOP1i moiety binds to TOP1 and stabilizes cleaved DNA-TOP1 complexes. This prevents DNA re-ligation, induces irreversible DNA strand breaks, prevents DNA repair, and leads to cycle arrest and apoptosis specifically in tumor cells expressing B7-H4. B7-H4, a member of the B7 family of immune modulators, is upregulated in a variety of tumor cell types and tumor-associated macrophages. It negatively regulates T-cell immune responses.",
  "synonyms": [
    "anti-B7-H4 ADC GSK5733584",
    "anti-B7-H4 antibody-drug conjugate GSK5733584",
    "anti-B7-H4/TOP1i ADC GSK5733584",
    "anti-B7-H4/topoisomerase I inhibitor ADC GSK5733584"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-b7-h4-top1i-antibody-drug-conjugate-gsk5733584/"
}