anti-B7-H4/anti-CD3 bispecific antibody GEN1047

{
  "id": "MLC-T-ONC-010149",
  "term": "anti-B7-H4/anti-CD3 bispecific antibody GEN1047",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific monoclonal antibody against both B7-H4 (V-set domain-containing T-cell activation inhibitor 1; VTCN1; B7x; B7S1) and T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-B7-H4/anti-CD3 bispecific antibody GEN1047 targets and binds to both B7-H4 on the surface of tumor cells and CD3 on T cells. This results in the cross-linking of tumor cells and T cells, and induces a cytotoxic T-lymphocyte (CTL) response against B7-H4-expressing tumor cells. B7-H4, a member of the B7 family of immune modulators, is upregulated in a variety of tumor cell types and negatively regulates T-cell immune responses.",
  "synonyms": [
    "DuoBody-CD3xB7H4 GEN1047"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-b7-h4-anti-cd3-bispecific-antibody-gen1047/"
}