anti-MAGE-A4 T-cell receptor/anti-CD3 scFv fusion protein IMC-C103C

{
  "id": "MLC-T-ONC-010875",
  "term": "anti-MAGE-A4 T-cell receptor/anti-CD3 scFv fusion protein IMC-C103C",
  "field": "Oncology and biomedicine",
  "definition": "A T-cell re-directing bi-specific biologic composed of a modified form of human T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) human melanoma-associated antigen A4 (MAGE-A4) and fused to an anti-CD3 single-chain variable fragment (scFv), with potential antineoplastic activity. Upon intravenous administration of IMC-C103C, the TCR moiety of this agent targets and binds to MAGE-A4 on tumor cells and the anti-CD3 scFv moiety binds to CD3- expressing T lymphocytes. This selectively cross-links tumor cells and T lymphocytes and results in a CTL-mediated death of MAGE-A4-expressing tumor cells. MAGE-A4 is overexpressed by a variety of cancer cell types.",
  "synonyms": [
    "ImmTAC IMC-C103C",
    "ImmTAC Molecule IMC-C103C",
    "immune mobilizing monoclonal TCR against cancer IMC-C103C",
    "T-cell redirecting bi-specific biologic IMC-C103C"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-mage-a4-t-cell-receptor-anti-cd3-scfv-fusion-protein-imc-c103c/"
}