autologous genetically-modified MAGE-A4 C1032 CD8alpha T cells

{
  "id": "MLC-T-ONC-011633",
  "term": "autologous genetically-modified MAGE-A4 C1032 CD8alpha T cells",
  "field": "Oncology and biomedicine",
  "definition": "Autologous human T lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the human melanoma antigen A4 (MAGE-A4) and the CD8alpha co-receptor, with potential immunostimulatory and antineoplastic activities. Upon leukapheresis, isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous genetically-modified MAGE-A4 C1032 CD8alpha T cells bind to tumor cells expressing MAGE-A4. This may result in both inhibition of growth and increased cell death of MAGE-A4-expressing tumor cells. The tumor-associated antigen MAGE-A4, a member of the MAGE-A family of cancer testis antigens, is overexpressed by a variety of cancer cell types. Co-expression of CD8alpha may broaden the immune response against tumors and increase antitumor activity by converting CD4+ helper T cells into CD8+ cytotoxic T cells.",
  "synonyms": [
    "autologous TCR-transduced MAGE-A4 C1032 CD8alpha T cells",
    "MAGE-A4-specific TCR gene-transduced C1032 CD8alpha T lymphocytes",
    "ADP-A2M4CD8",
    "autologous genetically-modified MAGE-A4 C1032 CD8alpha T lymphocytes",
    "MAGE-A4 SPEAR CD8alpha T cells",
    "autologous MAGE-A4 C1032 TCR-modified CD8alpha T cells",
    "SPEAR T-cell ADP-A2M4CD8",
    "autologous genetically-modified melanoma antigen A4 CD8alpha T cells",
    "MAGE-A4 SPEAR CD8alpha T-cells",
    "MAGE-A4-specific TCR gene-transduced C1032 CD8alpha T-lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-genetically-modified-mage-a4-c1032-cd8alpha-t-cells/"
}