autologous MAGE-A10-specific HLA-A2-restricted TCR c796 gene-engineered lymphocytes

{
  "id": "MLC-T-ONC-011682",
  "term": "autologous MAGE-A10-specific HLA-A2-restricted TCR c796 gene-engineered lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Human autologous T lymphocytes transduced with a retroviral vector encoding a high-affinity T-cell receptor (TCR) specific for human leukocyte antigen (HLA)-A2-restricted, human melanoma-associated antigen A10 (MAGE-A10), clone 796 (c796), with potential antineoplastic activity. Peripheral blood mononuclear cells (PBMCs) are isolated from a patient, transduced with an anti-MAGE-A10(c796)-HLA-A2 restricted TCR, expanded ex vivo, and reintroduced into the HLA-A2-positive patient. Upon reintroduction, the autologous MAGE-A10-specific, HLA-A2-restricted TCR c796 gene-engineered lymphocytes bind to tumor cells expressing the MAGE-A10 antigen, which may induce cell death in and halt the growth of MAGE-A10-expressing cancer cells. The tumor-associated antigen MAGE-A10, a member of the MAGE-A family of cancer/testis tumor-associated antigens (CT-TAAs), is overexpressed by a variety of cancer cell types.",
  "abbreviation": "MAGEA10c796 T",
  "synonyms": [
    "autologous genetically-modified T cells MAGEA10c796",
    "autologous MAGE A10c796 T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-mage-a10-specific-hla-a2-restricted-tcr-c796-gene-engineered/"
}