Autologous lymphoma immunoglobulin-derived scFV-chemokine DNA vaccine

{
  "id": "MLC-T-ONC-011681",
  "term": "Autologous lymphoma immunoglobulin-derived scFV-chemokine DNA vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A plasmid DNA vaccine encoding an autologous lymphoma-derived idiotype-targeting immunoglobulin (Ig)-derived single chain variable fragment (scFv) fused to the chemokine macrophage inflammatory protein 3 alpha (MIP3a), with potential immunostimulating and antineoplastic activities. Upon intramuscular vaccination, the autologous lymphoma immunoglobulin-derived scFv-chemokine DNA vaccine is taken up by antigen-presenting cells (APCs) and stimulates the immune system to exert a cytotoxic T-lymphocyte (CTL) response against the idiotype expressed on the surface of B lymphoma cells. MIP3a, also called chemokine (C-C motif) ligand 20 (CCL20), is a chemotactic cytokine able to enhance the immune response through binding to chemokine receptors expressed on APCs.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-lymphoma-immunoglobulin-derived-scfv-chemokine-dna-vaccine/"
}