ulocuplumab

{
  "id": "MLC-T-ONC-017393",
  "term": "ulocuplumab",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable monoclonal antibody against CXC chemokine receptor 4 (CXCR4) with potential antineoplastic activity. Ulocuplumab binds to the chemokine receptor CXCR4, preventing the binding of stromal derived factor-1 (SDF-1) to the CXCR4 receptor and subsequent receptor activation, which may result in decreased tumor cell proliferation and migration. CXCR4, a chemokine receptor belonging to the G protein-coupled receptor family, plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types.",
  "synonyms": [
    "anti-CXCR4 monoclonal antibody MDX-1338"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ulocuplumab/"
}