SDF-1 receptor antagonist PTX-9908

{
  "id": "MLC-T-ONC-016658",
  "term": "SDF-1 receptor antagonist PTX-9908",
  "field": "Oncology and biomedicine",
  "definition": "A stromal cell-derived factor 1 (SDF-1; CXCL12) analog and inhibitor of C-X-C chemokine receptor type 4 (CXCR4), with potential antineoplastic activity. Upon administration, PTX-9908 selectively targets and binds to CXCR4, thereby preventing the binding of CXCR4 to its ligand SDF-1. This inhibits receptor activation and results in decreased proliferation and migration of CXCR4-overexpressing tumor cells. The G protein-coupled receptor CXCR4, which is overexpressed in several tumor cell types, promotes tumor angiogenesis, tumor cell proliferation, survival, invasion and metastasis. SDF-1, a major chemotactic factor, plays a key role in mediating cell trafficking via selective binding to CXCR4.",
  "synonyms": [
    "CXCR4 antagonist CTCE-9908",
    "SDF-1 analog PTX-9908"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/sdf-1-receptor-antagonist-ptx-9908/"
}