MAGE-A4-specific T-cell engager CDR404

{
  "id": "MLC-T-ONC-014972",
  "term": "MAGE-A4-specific T-cell engager CDR404",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific T-cell engaging antibody directed against the human leukocyte antigen (HLA)-A2-restricted tumor-associated antigen (TAA) human melanoma-associated antigen A4 (MAGE-A4) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon intravenous administration of the MAGE-A4-specific T-cell engager (TCE) CDR404, the anti-MAGE-A4 moiety targets and binds to MAGE-A4 presented on HLA-A2 on tumor cells and the anti-CD3 moiety binds to CD3- expressing cytotoxic T lymphocytes (CTLs). This selectively cross-links tumor cells and T lymphocytes and results in a CTL-mediated death of MAGE-A4-expressing tumor cells. MAGE-A4 is overexpressed by a variety of cancer cell types.",
  "synonyms": [
    "anti-MAGE-A4/anti-CD3 bispecific antibody CDR404",
    "MAGE-A4 M-gager CDR404",
    "MAGE-A4-targeting T-cell engager CDR404",
    "TCE CDR404"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mage-a4-specific-t-cell-engager-cdr404/"
}