anti-HLA-A*02/NY-ESO-1 bispecific T-cell engager DS-2243a

{
  "id": "MLC-T-ONC-010789",
  "term": "anti-HLA-A*02/NY-ESO-1 bispecific T-cell engager DS-2243a",
  "field": "Oncology and biomedicine",
  "definition": "A T-cell engaging bispecific antibody directed against the tumor-associated antigen (TAA) NY-ESO-1 complexed with human leukocyte antigen (HLA)-A*02 (HLA-A*02) and an antigen found on T lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, anti-HLA-A*02/NY-ESO-1 bispecific T-cell engager DS-2243a targets and binds to an antigen found on cytotoxic T lymphocytes (CTLs) and NY-ESO-1 presented by HLA-A*02 expressed on tumor cells. This activates and redirects CTLs to NY-ESO-1-expressing tumor cells, which results in the CTL-mediated cell death of NY-ESO-1-expressing tumor cells. NY-ESO-1, a cell surface protein expressed in normal fetal and adult testes, is upregulated in a variety of tumor cell types as a HLA-A*02/NY-ESO-1 complex.",
  "synonyms": [
    "anti-NY-ESO-1 T-cell engaging bispecific antibody DS-2243a",
    "bispecific T-cell engager anti-HLA-A*02/NY-ESO-1 DS-2243a",
    "bispecific TCE DS-2243a"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-hla-a-02-ny-eso-1-bispecific-t-cell-engager-ds-2243a/"
}