anti-MAGE-A4/anti-CD3 bispecific antibody RO7617991

{
  "id": "MLC-T-ONC-010876",
  "term": "anti-MAGE-A4/anti-CD3 bispecific antibody RO7617991",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific T-cell engaging antibody directed against both the tumor-associated antigen (TAA) melanoma-associated antigen A4 (MAGE-A4) and T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-MAGE-A4/anti-CD3 bispecific antibody RO7617991 simultaneously binds to both CD3 on cytotoxic T lymphocytes (CTLs) and MAGE-A4 on MAGE-A4-expressing tumor cells. This activates and redirects CTLs to MAGE-A4-expressing tumor cells, which results in the CTL-mediated cell death of MAGE-A4-expressing tumor cells. MAGE-A4 is overexpressed by a variety of cancer cell types.",
  "synonyms": [
    "anti-MAGE-A4/CD3 bispecific antibody RO7617991",
    "MAGE-A4 x CD3 bispecific antibody RO7617991"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-mage-a4-anti-cd3-bispecific-antibody-ro7617991/"
}