gallium Ga 68 FF58

{
  "id": "MLC-T-ONC-013825",
  "term": "gallium Ga 68 FF58",
  "field": "Oncology and biomedicine",
  "definition": "A radiopharmaceutical agent comprised of FF58, a non-arginine-glycine-aspartic acid (Arg-Gly-Asp/RGD) small molecule targeting the transmembrane receptors integrin alpha V beta 3 (avb3) and 5 (avb5), labeled with gallium Ga 68, with potential avb3/5 imaging activity during positron emission topography (PET)/computed tomography (CT). After intravenous administration of gallium Ga 68 FF58, the FF58 moiety selectively targets and binds to avb3/5 on the tumor cell membrane. Upon PET/CT imaging, avb3/5-expressing tumor cells can be visualized and their expression levels can be quantified. avb3/5, members of the integrin receptor family, are overexpressed on certain tumor cells and tumor endothelial cells while minimally or not expressed on healthy, normal cells; they play key roles in angiogenesis, tumor proliferation and survival.",
  "synonyms": [
    "68Ga-FF58",
    "[68Ga]-FF58",
    "gallium Ga 68-FF58"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-ff58/"
}