gallium Ga 68 gozetotide

{
  "id": "MLC-T-ONC-013826",
  "term": "gallium Ga 68 gozetotide",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of a human prostate specific membrane antigen (PSMA)-targeting ligand, Glu-urea-Lys(Ahx) (Glu-NH-CO-NH-Lys(Ahx)), conjugated, via the acyclic radiometal chelator N,N'-bis [2-hydroxy-5-(carboxyethyl)benzyl] ethylenediamine-N,N'-diacetic acid (HBED-CC), to the radioisotope gallium Ga 68, with potential use as a tracer for PSMA-expressing tumors during positron emission tomography (PET). Upon intravenous administration of the gallium Ga 68 gozetotide, the Glu-urea-Lys(Ahx) moiety targets and binds to PSMA-expressing tumor cells. Upon internalization, PSMA-expressing tumor cells can be detected during PET imaging. PSMA, a tumor-associated antigen and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells.",
  "synonyms": [
    "68Ga-PSMA",
    "PSMA-HBED-CC GA-68",
    "gallium-68 PSMA ligand Glu-urea-Lys(Ahx)-HBED-CC",
    "68Ga-HBED-CC-PSMA",
    "68Ga-DKFZ-PSMA-11",
    "Ga PSMA",
    "68Ga-labeled Glu-NH-CO-NH-Lys(Ahx)-HBED-CC",
    "gallium-68 PSMA",
    "gallium Ga 68 PSMA-11",
    "68Ga-PSMA-HBED-CC",
    "(68)gallium-PSMA ligand Glu-urea-Lys(Ahx)-HBED-CC",
    "GaPSMA",
    "68Ga-PSMA-11",
    "(68)Ga-PSMA ligand Glu-urea-Lys(Ahx)-HBED-CC",
    "[68Ga]GaPSMA-11",
    "(68Ga)Glu-urea-Lys(Ahx)-HBED-CC",
    "(68)Ga-labeled Glu-urea-Lys(Ahx)-HBED-CC",
    "Ga-68 labeled DKFZ-PSMA-11",
    "[68Ga] prostate-specific membrane antigen 11",
    "gallium Ga 68-labeled PSMA-11",
    "(68)Ga labeled Glu-NH-CO-NH-Lys(Ahx)-HBED-CC",
    "Ga-68 labeled PSMA-11",
    "GA-68 PSMA-11"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-gozetotide/"
}