Gallium Ga 68-HBED-CC-exendin-4

{
  "id": "MLC-T-ONC-013848",
  "term": "Gallium Ga 68-HBED-CC-exendin-4",
  "field": "Oncology and biomedicine",
  "definition": "A radiopharmaceutical composed of the glucagon-like peptide 1 receptor (GLP-1R) agonist exendin-4 linked by the acyclic radiometal chelator N,N'-bis [2-hydroxy-5-(carboxyethyl)benzyl] ethylenediamine-N,N'-diacetic acid (HBED-CC) to the positron-emitting radionuclide gallium Ga 68, with potential imaging activity upon positron emission tomography (PET)/computed tomography (CT). Upon administration of gallium Ga 68-HBED-CC-exendin-4, the exendin-4 moiety binds to GLP-1R. The radionuclide moiety can be detected using PET/CT and GLP-1R-expressing tumors can be localized. GLP-1R, located on beta cells, is overexpressed on insulinomas, which are insulin-secreting neuroendocrine tumors.",
  "synonyms": [
    "[68Ga]Ga-HBED-CC-exendin-4",
    "68Ga-HBED-CC-exendin-4",
    "[68Ga]-HBED-CC-exendin-4"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-hbed-cc-exendin-4/"
}