gallium Ga 68-HA-DOTA-TATE

{
  "id": "MLC-T-ONC-013847",
  "term": "gallium Ga 68-HA-DOTA-TATE",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate consisting of consisting of the high affinity somatostatin analogue iodo-tyrosine-3-octreotate (HA-TATE), labeled with the positron emission tomography (PET) tracer gallium Ga 68 via the macrocyclic chelating agent 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra-acetic acid (DOTA), which may be used as a human somatostatin receptor (SSTR) imaging agent in conjunction with PET to image neuroendocrine tumors (NETs). Gallium Ga 68-HA-DOTATATE binds to SSTRs, with high affinity for SSTR2, present on the cell membranes of many types of NETs. This allows for visualization of SSTR-positive cells upon imaging. SSTRs have been shown to be present in large numbers on NETs and their metastases, while most other normal tissues express low levels of SSTRs. HA-TATE is an octreotide derivative in which phenylalanine at position 3 is substituted with iodo-tyrosine and threoninol at position 8 is replaced by threonine. The iodo addition in Gallium Ga 68-HA-DOTA-TATE may allow for higher affinity for the SSTRs when compared to gallium Ga 68-DOTA-TATE.",
  "synonyms": [
    "68Ga-DOTA-3-iodo-Tyr3-octreotate",
    "68Ga-DOTA-iodoTyr3-octreotate",
    "68Ga-HA-DOTATATE",
    "[68Ga]DOTA-3-iodo-Tyr3-octreotate",
    "[68Ga]high-affinity DOTATATE"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-ha-dota-tate/"
}