gallium Ga 68-edotreotide

{
  "id": "MLC-T-ONC-013845",
  "term": "gallium Ga 68-edotreotide",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate consisting of the octreotide derivative edotreotide labeled with gallium 68 (Ga-68) with potential application in somatostatin receptor (SSTR) imaging in conjunction with positron emission tomography (PET). Similar to octreotide, gallium Ga 68-edotreotide binds to SSTRs, especially type 2 receptors, present on the cell membranes of many types of neuroendocrine tumor cells and their metastases, thereby allowing for imaging of SSTR-expressing cells upon PET. Gallium Ga 68-edotreotide is produced by substituting tyrosine for phenylalanine at the 3 position of the somatostatin analogue octreotide (Tyr3-octreotide or TOC) and chelating the substituted octreotide to Ga-68 via the macrocyclic chelating agent dodecanetetraacetic acid (DOTA).",
  "synonyms": [
    "Ga-68 DOTATOC",
    "Ga-68 DOTA0-Tyr3-octreotide",
    "gallium Ga 68-DOTATOC",
    "Ga-68-DOTA-TOC",
    "Ga-68-DOTA-tyr(3)-octreotide",
    "Ga-68-[Tyr3]-octreotide",
    "68Ga-DOTA-TOC",
    "68Ga-DOTA-d-Phe1-Tyr3-octreotide"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-edotreotide/"
}