yttrium Y 90-edotreotide

{
  "id": "MLC-T-ONC-009451",
  "term": "yttrium Y 90-edotreotide",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance being studied in the treatment of some types of cancer. Yttrium Y 90-edotreotide contains a molecule that binds to a protein found on certain types of neuroendocrine tumors (tumors that form from cells that release hormones). It also contains a radioactive substance called yttrium Y 90, which may help kill cancer cells. Yttrium Y 90-edotreotide is a type of radioconjugate. Also called yttrium Y 90-DOTA-tyr3-octreotide and yttrium Y 90-SMT 487.",
    "A radioconjugate consisting of the octreotide derivative edotreotide labeled with yttrium 90 (Y-90) with potential radiotherapeutic uses. Similar to octreotide, yttrium Y 90-edotreotide binds to somatostatin receptors (SSTRs), especially type 2 receptors, present on the cell membranes of many types of neuroendocrine tumor cells, delivering tissue-specific, beta-emitting nuclide Y-90-mediated cytotoxicity to SSTR-positive cells. Yttrium Y 90-edotreotide is produced by substituting tyrosine for phenylalanine at the 3 position of the somatostatin analogue octreotide and chelating the substituted octreotide to Y-90 via dodecanetetraacetic acid (DOTA)."
  ],
  "synonyms": [
    "yttrium Y 90-DOTA-tyr3-octreotide",
    "yttrium Y 90-SMT 487",
    "yttrium Y 90 -DOTATOC",
    "Y90-DOTA-tyr3-octreotide",
    "yttrium Y 90 SMT 487",
    "90Y-DOTA-3-Tyr-octreotide",
    "yttrium Y 90-DOTA-3-tyrosine-octreotide"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/yttrium-y-90-edotreotide/"
}