Yttrium Y 90-DOTA-girentuximab

{
  "id": "MLC-T-ONC-017641",
  "term": "Yttrium Y 90-DOTA-girentuximab",
  "field": "Oncology and biomedicine",
  "definition": "A radioimmunoconjugate comprised of girentuximab conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) and lableled with the beta-emitting radioisotope yttrium Y 90. The antibody moiety of yttrium Y 90-DOTA-girentuximab binds to renal cell carcinoma cells expressing the G250 antigen, thereby selectively delivering a cytotoxic dose of beta radiation.",
  "abbreviation": "90Y-DOTA-cG250",
  "synonyms": [
    "yttrium Y 90 DOTA chimeric monoclonal antibody cG250"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/yttrium-y-90-dota-girentuximab/"
}