yttrium Y 90-DOTA anti-CEA monoclonal antibody M5A

{
  "id": "MLC-T-ONC-009446",
  "term": "yttrium Y 90-DOTA anti-CEA monoclonal antibody M5A",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance being studied in the treatment of some types of cancer. M5A is a monoclonal antibody that binds to a protein called CEA, which is found on some cancer cells. It is linked to a radioactive substance called yttrium Y 90, which may help kill cancer cells. Yttrium Y 90-DOTA anti-CEA monoclonal antibody M5A is a type of radioimmunoconjugate.",
    "A radioimmunoconjugate consisting of a monoclonal antibody directed against the human carcinoembryonic antigen (CEA) conjugated with the radioisotope yttrium 90 (Y-90) via the chelator tetra-azacyclododecanetetra-acetic acid (DOTA) with potential antineoplastic activity. The antibody moiety of yttrium Y 90 DOTA anti-CEA monoclonal antibody M5A binds to cells expressing the CEA antigen. Upon cellular internalization, this agent selectively delivers a cytotoxic dose of beta radiation. CEA, a tumor associated antigen, is overexpressed in many cancer types, including gastrointestinal, breast, non-small cell lung, and thyroid cancers."
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/yttrium-y-90-dota-anti-cea-monoclonal-antibody-m5a/"
}