actinium Ac 225-DOTA-anti-CEA monoclonal antibody M5A

{
  "id": "MLC-T-ONC-009623",
  "term": "actinium Ac 225-DOTA-anti-CEA monoclonal antibody M5A",
  "field": "Oncology and biomedicine",
  "definition": "A radioimmunoconjugate comprised of M5A, a humanized monoclonal antibody directed against carcinoembryonic antigen-related cell adhesion molecule 5 (CEA or CEACAM5), conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA), and labeled with the alpha-emitting radioisotope actinium Ac 225, with potential antineoplastic activity. Upon administration, the monoclonal antibody moiety of actinium Ac 225-DOTA-anti-CEA monoclonal antibody M5A specifically targets and binds to CEA, thereby delivering a cytotoxic dose of alpha radiation to CEA-expressing tumor cells. CEA, a tumor-associated antigen (TAA) and a member of the CEA family of proteins, plays a key role in cell migration, cell invasion and cell adhesion, and is overexpressed by a variety of cancer types.",
  "synonyms": [
    "225Ac-DOTA-anti-CEA monoclonal antibody M5A",
    "225Ac-DOTA-M5A humanized anti-CEA antibody"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/actinium-ac-225-dota-anti-cea-monoclonal-antibody-m5a/"
}