actinium Ac 225-DOTA-h11B6 JNJ-69086420

{
  "id": "MLC-T-ONC-009625",
  "term": "actinium Ac 225-DOTA-h11B6 JNJ-69086420",
  "field": "Oncology and biomedicine",
  "definition": "A radioimmunoconjugate containing h11B6, a humanized immunoglobulin G1 (IgG1) monoclonal antibody that targets human kallikrein-2 (hK2), conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA), and labeled with the alpha-emitting radioisotope actinium Ac 225, with potential antineoplastic activity. Upon administration of actinium Ac 225-DOTA-h11B6 JNJ-69086420, the monoclonal antibody moiety of JNJ-69086420 targets and binds to hK2, thereby delivering a cytotoxic dose of alpha radiation to hK2-expressing tumor cells. hK2 is overexpressed on a variety of cancer cells.",
  "synonyms": [
    "225Ac-h11B6 JNJ-69086420",
    "[225Ac]-DOTA-h11B6",
    "actinium-225-labeled h11B6 JNJ-69086420",
    "actinium-225-labeled anti-kallikrein-2 h11B6 JNJ-69086420"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/actinium-ac-225-dota-h11b6-jnj-69086420/"
}