Actinium Ac 225 lintuzumab

{
  "id": "MLC-T-ONC-009617",
  "term": "Actinium Ac 225 lintuzumab",
  "field": "Oncology and biomedicine",
  "definition": "A radioimmunoconjugate consisting of the humanized monoclonal antibody lintuzumab conjugated to the alpha-emitting radioisotope actinium Ac 225 with potential antineoplastic activity. The monoclonal antibody moiety of actinium Ac 225 lintuzumab specifically binds to the cell surface antigen CD33 antigen, delivering a cytotoxic dose of alpha radiation to cells expressing CD33. CD33 is a cell surface antigen expressed on normal non-pluripotent hematopoietic stem cells and overexpressed on myeloid leukemia cells.",
  "synonyms": [
    "actinium-225-labeled humanized anti-CD33 monoclonal antibody HuM195",
    "225Ac-HuM195",
    "actinium (225Ac) lintuzumab satetraxetan"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/actinium-ac-225-lintuzumab/"
}