Actinium Ac 225 PSMA-R2

{
  "id": "MLC-T-ONC-009618",
  "term": "Actinium Ac 225 PSMA-R2",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of PSMA-R2, a human prostate-specific membrane antigen (PSMA)-targeting ligand, conjugated to the alpha-emitting radioisotope actinium Ac 225, with potential antineoplastic activity against PSMA-expressing tumor cells. Upon intravenous administration of 225Ac-PSMA-R2, the PSMA-R2 moiety targets and binds to PSMA-expressing tumor cells. Upon binding, PSMA-expressing tumor cells are destroyed by a cytotoxic dose of alpha radiation. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on the majority of prostate tumor cells.",
  "synonyms": [
    "225Ac-labeled PSMA-R2",
    "225Ac-PSMA-R2",
    "225AcPSMA-R2",
    "[225Ac]Ac-PSMA-R2",
    "Ac225-PSMA-R2",
    "actinium (225Ac) PSMA-R2",
    "actinium-225 PSMA-R2"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/actinium-ac-225-psma-r2/"
}