actinium Ac 225-PSMA-trillium

{
  "id": "MLC-T-ONC-009629",
  "term": "actinium Ac 225-PSMA-trillium",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of PSMA-trillium, a human prostate-specific membrane antigen (PSMA)-targeting small molecule that is linked to an albumin-binding moiety, and conjugated to the alpha-emitting radioisotope actinium Ac 225, with potential antineoplastic activity. Upon administration, actinium Ac 225-PSMA-trillium targets and binds to PSMA-expressing tumor cells. Upon binding, the radioisotope moiety delivers a cytotoxic dose of alpha radiation to PSMA-expressing tumor cells. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells as well as a variety of other solid tumors. The albumin-binding moiety targets and binds to albumin, which may improve therapeutic efficacy and reduce side effects in normal organs.",
  "synonyms": [
    "225Ac-labeled PSMA-trillium",
    "225Ac-PSMA-trillium"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/actinium-ac-225-psma-trillium/"
}