actinium Ac 225-FPI-1434

{
  "id": "MLC-T-ONC-009628",
  "term": "actinium Ac 225-FPI-1434",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate consisting of veligrotug, a humanized monoclonal antibody directed against insulin-like growth factor-1 receptor (IGF-1R) linked, via a bifunctional chelate, to the alpha-emitting radioisotope actinium Ac 225, with potential antineoplastic activity. Upon administration of actinium Ac 225-FPI-1434, the veligrotug moiety targets and binds to IGF-1R expressed on tumor cells. Upon binding, the radioisotope moiety delivers a cytotoxic dose of alpha radiation to IGF-1R-expressing tumor cells. Activation of IGF-1R, a receptor tyrosine kinase of the insulin receptor superfamily overexpressed by various cancer cell types, stimulates cell proliferation, promotes angiogenesis, enables oncogenic transformation, and suppresses apoptosis.",
  "synonyms": [
    "[Ac-225]-FPI-1434",
    "225Ac-FPI-1434",
    "actinium Ac 225-labeled FPI-1434",
    "actinium Ac 225-FPI-1397-FPI-1175"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/actinium-ac-225-fpi-1434/"
}