actinium Ac 225 FPI-2059

{
  "id": "MLC-T-ONC-009615",
  "term": "actinium Ac 225 FPI-2059",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate consisting of a neurotensin receptor type 1 (NTSR1)-targeting small molecule antagonist labeled with the alpha-emitting radioisotope actinium Ac 225, with potential antineoplastic activity. Upon administration of actinium Ac 225 FPI-2059, the NTSR1-targeting moiety targets and binds to NTSR1 expressed on tumor cells. Upon binding, the radioisotope moiety delivers a cytotoxic dose of alpha radiation to NTSR1-expressing tumor cells. NTSR1, a G protein-coupled receptor for the tridecapeptide neurotensin (NTS), is overexpressed in certain types of cancers and plays a key role in tumor cell proliferation.",
  "synonyms": [
    "[225Ac]-FPI-2059",
    "Ac 225 FPI-2059",
    "225Ac-FPI-2059"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/actinium-ac-225-fpi-2059/"
}