Actinium Ac 225-FL-020

{
  "id": "MLC-T-ONC-009627",
  "term": "Actinium Ac 225-FL-020",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of FL-020, a human prostate-specific membrane antigen (PSMA)-targeting ligand, conjugated to the alpha-emitting radioisotope actinium Ac 225, with potential antineoplastic activity. Upon administration of actinium Ac 225-FL-020, FL-020 targets and binds to PSMA-expressing tumor cells. Upon binding, the radioisotope moiety delivers a cytotoxic dose of alpha radiation to PSMA-expressing tumor cells. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells as well as a variety of other solid tumors.",
  "synonyms": [
    "[225Ac]-FL-020",
    "[225Ac]Ac-FL-020",
    "actinium Ac 225 FL-020",
    "actinium Ac 225-labeled FL-020"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/actinium-ac-225-fl-020/"
}