actinium Ac 225 rosopatamab tetraxetan

{
  "id": "MLC-T-ONC-009619",
  "term": "actinium Ac 225 rosopatamab tetraxetan",
  "field": "Oncology and biomedicine",
  "definition": "A radioimmunoconjugate consisting of a humanized monoclonal antibody directed against prostate specific membrane antigen (PSMA) labeled with the alpha particle-emitting radioisotope actinium Ac-225, with potential antineoplastic activity. Upon administration, actinium Ac 225 rosopatamab tetraxetan binds to the extracellular domain of PSMA with high affinity, thereby delivering alpha radiation to PSMA expressing cells. PSMA, a type II membrane protein expressed in all types of prostatic tissues, is often overexpressed in tumor cells.",
  "abbreviation": "225Ac-J591",
  "synonyms": [
    "Ac 225 monoclonal antibody J591",
    "Ac 225 MOAB J591",
    "actinium Ac-225 anti-prostate-specific membrane antigen monoclonal antibody J591",
    "actinium Ac-225 anti-PSMA monoclonal antibody J591"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/actinium-ac-225-rosopatamab-tetraxetan/"
}