gallium Ga 68-NODAGA-LM3

{
  "id": "MLC-T-ONC-013863",
  "term": "gallium Ga 68-NODAGA-LM3",
  "field": "Oncology and biomedicine",
  "definition": "A radiopharmaceutical agent comprised of LM3, a human somatostatin receptor (SSTR) antagonist, chelated with 1,4,7-triazacyclononane,1-glutaric acid-4,7 acetic acid (NODAGA) and radiolabeled with gallium Ga 68, that may be used as an imaging agent for SSTR-expressing tumor cells upon positron emission tomography (PET). Upon administration of gallium Ga 68 NODAGA-LM3, the LM3 moiety targets and binds to SSTRs that are present on the cell membranes of many types of neuroendocrine tumors (NETs). This allows for visualization of SSTR-positive cells upon PET imaging. SSTRs have been shown to be present in large numbers on NETs and their metastases, while most other normal tissues express low levels of SSTRs.",
  "synonyms": [
    "(68)Ga-NODAGA-LM3",
    "gallium-68 labeled LM3",
    "68Ga-1,4,7-triazacyclononane, 1-glutaric acid-4,7-acetic acid-LM3",
    "68Ga-NODAGA-p-Cl-Phe-cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr-NH(2)"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-nodaga-lm3/"
}