gallium Ga 68-NODAGA-ZIGF-1R:4:40

{
  "id": "MLC-T-ONC-013864",
  "term": "gallium Ga 68-NODAGA-ZIGF-1R:4:40",
  "field": "Oncology and biomedicine",
  "definition": "A radiolabeled recombinant insulin-like growth factor 1 receptor (IGF-1R; IGF1R)-specific affibody ligand composed of an IGF1R-targeting protein, the anti-IGF1R affibody ZIGF-1R:4:40 with an acetylated cysteine (Ac-Cys) at the N terminal of the affibody, that is site-specifically conjugated with the chelating agent NODAGA (1,4,7-triazacyclononane,1-glutaric acid-4,7-acetic acid), and labeled with the radioisotope gallium Ga 68, with potential use for imaging IGF1R-expressing tumor cells upon positron emission tomography (PET). Upon administration of gallium Ga 68-NODAGA-ZIGF-1R:4:40, the ZIGF-1R:4:40 affibody molecule moiety targets and binds to IGF1R expressed on various tumor cell types. Upon PET, IGF1R-expressing tumor cells can be visualized. IGF1R, frequently overexpressed in cancers, plays important roles in cell proliferation, survival, adhesion, migration, and differentiation. The affibody protein scaffold is based on the Z-domain, which is derived from one of the immunoglobulin (Ig) G-binding domains of staphylococcal protein A.",
  "synonyms": [
    "68Ga-NODAGA-ZIGF-1R:4:40",
    "68Ga-NODAGA-ZIGF-1R:4Z:40",
    "[68Ga]-labeled anti-IGF-1R affibody molecule ZIGF-1R:4:40"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-nodaga-zigf-1r-4-40/"
}