gallium Ga 68-labeled affibody ABY-025

{
  "id": "MLC-T-ONC-013850",
  "term": "gallium Ga 68-labeled affibody ABY-025",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of an optimized affibody conjugated, via its C-terminal cysteine, to maleimide-DOTA, and linked to the radioisotope gallium Ga 68, with potential use as a tracer for human epidermal growth factor receptor type 2 (HER2; ErbB2)-expressing tumors using positron emission tomography (PET). Upon intravenous administration of the gallium Ga 68-labeled affibody ABY-025, the affibody targets HER2-expressing tumor cells. This facilitates both detection of HER2-expressing tumor cells and assessment of responses to HER2-targeting chemotherapeutic agents during PET imaging. The affibody is an optimized antibody mimetic based on a 6.5-kDa 3-helical bundle Z domain derived from the staphylococcal protein A (Z her2:342); the nonbinding surface of the Z domain is reengineered (Z her2:2891) to increase binding affinity for HER2 and to improve tumor imaging. HER2 is overexpressed in many cancer cell types.",
  "abbreviation": "[68Ga]ABY-025",
  "synonyms": [
    "gallium Ga 68-maleimide-DOTA-Cys61-ZHER2:2891-Cys",
    "gallium Ga 68-[maleimide-DOTA-Cys61]-ZHER2:2891-Cys"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-labeled-affibody-aby-025/"
}