technetium Tc-99m anti-HER2 affibody ABH2

{
  "id": "MLC-T-ONC-017030",
  "term": "technetium Tc-99m anti-HER2 affibody ABH2",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of an optimized affibody labeled with technetium Tc 99m, with potential use as a tracer for human epidermal growth factor receptor type 2 (HER2; ErbB2)-expressing tumors using single photon emission computed tomography (SPECT). Upon administration, the Tc 99m-labeled affibody ABH2 targets and binds to HER2-expressing tumor cells. This facilitates both detection of HER2-expressing tumor cells and assessment of responses to HER2-targeting chemotherapeutic agents using SPECT. HER2, a receptor tyrosine kinase, is mutated in many tumor cell types and plays a key role in tumor cell proliferation and tumor vascularization.",
  "synonyms": [
    "99mTc-ABH2",
    "HER2-targeting 99mTc-labeled affibody"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/technetium-tc-99m-anti-her2-affibody-abh2/"
}