technetium Tc-99m-MIRC208

{
  "id": "MLC-T-ONC-017036",
  "term": "technetium Tc-99m-MIRC208",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of a nanobody directed against human epidermal growth factor receptor 2 (HER2; EGFR2; ERBB2) that is labeled with technetium Tc 99m, with potential use as a tracer for HER2-expressing tumors using single photon emission computed tomography/computed tomography (SPECT/CT). Upon administration of technetium Tc-99m-MIRC208, the anti-HER2 nanobody moiety targets and binds to HER2-expressing tumor cells. This facilitates both the detection of HER2-expressing tumor cells and the assessment of responses to HER2-targeting chemotherapeutic agents using SPECT/CT. HER2, a receptor tyrosine kinase, is overexpressed on the cell surfaces of various tumor cell types; it plays a key role in tumor cell proliferation and tumor vascularization.",
  "synonyms": [
    "technetium Tc 99m-MIRC208",
    "99mTc-MIRC208"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/technetium-tc-99m-mirc208/"
}