Technetium Tc 99m anti-HER2 affibody HPArk2

{
  "id": "MLC-T-ONC-017013",
  "term": "Technetium Tc 99m anti-HER2 affibody HPArk2",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of an affibody targeting human epidermal growth factor receptor 2 (HER2; EGFR2; ErbB2), labeled with technetium Tc 99m, with potential imaging activity using single photon emission computed tomography (SPECT)/computed tomography (CT). Upon administration, the anti-HER2 affibody moiety of technetium Tc-99m anti-HER2 affibody HPArk2 targets and binds to HER2-expressing tumor cells. Upon SPECT/CT imaging, HER2-expressing tumor cells can be detected. HER2, a receptor tyrosine kinase, is mutated in many tumor cell types and plays a key role in tumor cell proliferation and tumor vascularization.",
  "synonyms": [
    "99mTc-HPArk2",
    "99mTc-labeled HER2 affibody HPArk2",
    "technetium Tc-99m anti-HER2 antagonist HPArk2"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/technetium-tc-99m-anti-her2-affibody-hpark2/"
}