technetium Tc-99m DARPinG3

{
  "id": "MLC-T-ONC-017031",
  "term": "technetium Tc-99m DARPinG3",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of the scaffold protein DARPinG3, labeled with technetium Tc 99m, with potential imaging activity for human epidermal growth factor receptor 2 (HER2; EGFR2; ErbB2)-expressing tumor cells upon single photon emission computed tomography (SPECT)/computed tomography (CT). Upon administration of technetium Tc-99m DARPinG3, the DARPinG3 moiety targets and binds to HER2-expressing tumor cells. Upon SPECT/CT imaging, HER2-expressing tumor cells can be detected. HER2, a receptor tyrosine kinase, is mutated in many tumor cell types and plays a key role in tumor cell proliferation and tumor vascularization.",
  "synonyms": [
    "99mTc-DARPinG3",
    "99mTc-DARPin G3",
    "99mTc-labeled DARPinG3"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/technetium-tc-99m-darping3/"
}