Technetium Tc 99m trofolastat

{
  "id": "MLC-T-ONC-017023",
  "term": "Technetium Tc 99m trofolastat",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of an urea-based human prostate-specific membrane antigen (PSMA)-targeting ligand, conjugated to the gamma-emitting radioisotope technetium Tc 99m, with potential use as a tracer for PSMA-expressing tumors using single photon emission computed tomography/computed tomography (SPECT/CT). Upon intravenous administration of the technetium Tc 99m trofolastat, the trofolastat moiety targets and binds to PSMA-expressing tumor cells. Upon internalization, PSMA-expressing tumor cells can be detected during SPECT/CT imaging. PSMA, a tumor-associated antigen and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells.",
  "synonyms": [
    "99mTc-MIP 1404",
    "99mTc-MIP-1404"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/technetium-tc-99m-trofolastat/"
}