99mTc-based PSMA imaging and surgery agent

{
  "id": "MLC-T-ONC-009563",
  "term": "99mTc-based PSMA imaging and surgery agent",
  "field": "Oncology and biomedicine",
  "definition": "A diagnostic radioconjugate composed of a prostate-specific membrane antigen (PSMA)-targeting ligand that is linked, via the bifunctional, macrocyclic chelating agent 1,4,7,10-tetraazacyclododecane-1-(glutamic acid)-4,7,10-triacetic acid (DOTAGA; DOTA-GA), to the radioisotope technetium Tc 99m (Tc99m), that can potentially be used as a radioimaging agent for radio-guided surgery upon single-photon emission computed tomography (SPECT)/computed tomography (CT) for PSMA-overexpressing tumor cells. Upon administration, 99mTc-based PSMA-imaging and surgery (I&S agent targets and binds to PSMA on PSMA-expressing tumor cells. Upon SPECT/CT imaging, PSMA-expressing tumors can be visualized and identified. PSMA, a tumor-associated antigen (TAA), is overexpressed by most prostate cancers.",
  "synonyms": [
    "99mTc-based PSMA for imaging and surgery",
    "99mTc-DOTAGA-(3-iodo-y)-f-k-Sub(KuE)",
    "99mTc-labeled PSMA-targeting I&S SPECT/CT agent",
    "technetium Tc99m PSMA-targeting agent I&S"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/99mtc-based-psma-imaging-and-surgery-agent/"
}