PSMA-targeting agent-technetium Tc99m EC0652

{
  "id": "MLC-T-ONC-016285",
  "term": "PSMA-targeting agent-technetium Tc99m EC0652",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of 2-[3-(1, 3-dicarboxy propyl)-ureido] pentanedioic acid (DUPA), a prostate-specific membrane antigen (PSMA)-targeting ligand, linked to the radioisotope technetium Tc 99m (Tc99m), that can potentially be used as a radioimaging agent for PSMA-overexpressing tumor cells. Upon administration, the PSMA-targeting moiety of EC0652 targets and binds to PSMA-expressing tumors. Upon uptake and single-photon emission computed tomography (SPECT) imaging, PSMA-expressing tumors can be visualized and identified. In turn, PSMA-overexpression can be used to evaluate both the efficacy of and response to certain PSMA-targeting cytotoxic agents. PSMA, a tumor-associated antigen (TAA), is overexpressed by most prostate cancers.",
  "synonyms": [
    "radiodiagnostic EC0652",
    "99mTc-EC0652",
    "DUPA-99mTc EC0652",
    "DUPA-99mTc"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/psma-targeting-agent-technetium-tc99m-ec0652/"
}