Technetium Tc 99 hydrazinonicotinamide-tricine-linked interleukin-2

{
  "id": "MLC-T-ONC-017011",
  "term": "Technetium Tc 99 hydrazinonicotinamide-tricine-linked interleukin-2",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of the cytokine interleukin-2 (IL-2) conjugated to the bifunctional chelating agent succinimidyl-6-hydrazinopyridine-3-carboxylate (HYNIC-NHS) and co-ligand tricine and labeled with the radioisotope technetium Tc 99m (99mTc-HYNIC-IL2), that can potentially be used as a diagnostic agent to detect tumor inflammation. Upon intravenous administration, IL-2 selectively binds to the IL-2 receptor (IL-2R) expressed on tumor infiltrating lymphocytes (TILs); upon internalization, the Tc99m moiety can be visualized using radioimaging, which allows the quantification of TILs expressing IL-2R. This agent detects tumor enlargement due to invasion by TILs and not tumor progression.",
  "synonyms": [
    "99mTc-HYNIC-IL2"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/technetium-tc-99-hydrazinonicotinamide-tricine-linked-interleukin-2/"
}