Fluorine F 18 FAPI-74

{
  "id": "MLC-T-ONC-013670",
  "term": "Fluorine F 18 FAPI-74",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of FAPI-74, a quinoline-based fibroblast activation protein (FAP)-targeted tracer belonging to the group of FAP inhibitors (FAPi) conjugated to the bifunctional, macrocyclic chelating agent 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA) and labeled with the positron-emitting radioisotope fluorine F 18, with potential use as a tracer for FAP-expressing tumors and cancer-associated fibroblasts (CAFs) during positron emission tomography (PET). Upon administration of fluorine F 18 FAPI-74, the FAPI-74 moiety targets and binds to FAP-expressing tumor cells and FAP-expressing CAFs. Upon binding and internalization, FAP-expressing tumor cells and CAFs can be detected during PET imaging. FAP, a cell surface protein, is overexpressed in a variety of human cancer cell types and on CAFs in the tumor microenvironment (TME).",
  "synonyms": [
    "[18F]FAPI-74",
    "18F-FAPI-74"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fluorine-f-18-fapi-74/"
}