fluorine F 18-Al-NOTA-MATBBN

{
  "id": "MLC-T-ONC-013710",
  "term": "fluorine F 18-Al-NOTA-MATBBN",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate containing a bombesin (BBN) peptide analog, derived from an unspecified GRPR antagonist (MATBBN) that targets the gastrin-releasing peptide receptor (GRPR), and is linked to the radionuclide fluorine F 18 (18F), by the macrocyclic chelating agent, 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA), through a method that first couples 18F to aluminum (Al), with potential use in diagnostic imaging using positron emission tomography/computed tomography (PET/CT). Upon administration of fluorine F 18-Al-NOTA-MATBBN, the peptide moiety targets and binds to GRPR. Upon PET/CT, GRPR-expressing tumor cells can then be visualized. GRPR, also called bombesin receptor 2 (BB2), is a seven-transmembrane G protein-coupled receptor belonging to the bombesin receptor family. It is overexpressed in certain types of cancers. Bombesin is a peptide exhibiting high affinity for the gastrin-releasing peptide receptor (GRPR).",
  "synonyms": [
    "18F-Al-NOTA-MATBBN"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fluorine-f-18-al-nota-matbbn/"
}