gallium Ga 68-labeled RM2

{
  "id": "MLC-T-ONC-013857",
  "term": "gallium Ga 68-labeled RM2",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate containing a synthetic bombesin receptor antagonist targeting the gastrin-releasing peptide receptor (GRPR), that is linked by the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) to the radionuclide gallium (Ga) 68, with potential use in diagnostic imaging using positron emission tomography/computed tomography (PET/CT). Upon administration of gallium Ga 68 GRPR antagonist BAY86-7548, the peptide moiety targets and binds to GRPR. Upon PET/CT, GRPR-expressing tumor cells can then be visualized. GRPR, also called bombesin receptor 2 (BB2), is a G protein-coupled seven-transmembrane receptor belonging to the bombesin receptor family. It is overexpressed in certain types of cancers.",
  "synonyms": [
    "68Ga-DOTA-bombesin analog BAY86-7548",
    "gallium Ga68-labeled GRPR antagonist RM2",
    "[68Ga]RM2",
    "68Ga-bombesin antagonist BAY86-7548",
    "Ga-68-labeled bombesin antagonist BAY 86-7548",
    "(68)Ga-DOTA-4-amino-1-carboxymethylpiperidine-d-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2",
    "68Ga-DOTA RM2",
    "68-Ga RM2",
    "gallium Ga 68-labeled GRPR antagonist BAY86-7548",
    "[68Ga]-labeled bombesin analog BAY86-7548"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-labeled-rm2/"
}