copper Cu 64 SAR-bombesin

{
  "id": "MLC-T-ONC-012751",
  "term": "copper Cu 64 SAR-bombesin",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate containing bombesin (BBN), a tetra-decapeptide that binds with high affinity to the gastrin-releasing peptide receptor (GRPR), and linked, by the sarcophagine chelator (SAR), to the radionuclide copper Cu 64, with potential use in diagnostic imaging using positron emission tomography/computed tomography (PET/CT). Upon administration of copper Cu 64 SAR-BBN, the BBN moiety targets and binds to GRPR. Upon PET/CT, GRPR-expressing tumor cells can be visualized. GRPR, also called bombesin receptor 2 (BB2), is a seven-transmembrane G protein-coupled receptor belonging to the bombesin receptor family. It is overexpressed in certain types of cancers.",
  "synonyms": [
    "64Cu-SAR-bombesin",
    "64Cu-SAR-BBN"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/copper-cu-64-sar-bombesin/"
}