Copper Cu 67 SAR-bombesin

{
  "id": "MLC-T-ONC-012767",
  "term": "Copper Cu 67 SAR-bombesin",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of bombesin (BBN), a tetra-decapeptide that binds with high affinity to the gastrin-releasing peptide receptor (GRPR), linked by the sarcophagine chelator (SAR) and radiolabeled with the beta-emitting radioisotope copper Cu 67, with potential antineoplastic activity. Upon administration of copper Cu 67 SAR-BBN, the BBN moiety targets and binds to GRPR, thereby delivering a cytotoxic dose of beta radiation to GRPR-expressing tumor cells. GRPR, also called bombesin receptor 2 (BB2), is a seven-transmembrane G protein-coupled receptor belonging to the bombesin receptor family. It is overexpressed in certain types of cancers.",
  "synonyms": [
    "67Cu-SAR-bombesin",
    "67Cu-SAR-BBN",
    "copper Cu 67 SAR-BBN"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/copper-cu-67-sar-bombesin/"
}