Lead Pb 212-DOTAM-GRPR1

{
  "id": "MLC-T-ONC-014731",
  "term": "Lead Pb 212-DOTAM-GRPR1",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate consisting of a gastrin-releasing peptide receptor (GRPR)-targeting antagonist conjugated, through a bifunctional, macrocyclic chelating agent DOTAM (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic amide; TCMC), to the alpha-emitting radioisotope lead Pb 212, with potential antineoplastic activity. Upon administration, lead Pb 212-DOTAM-GRPR1 targets and binds to GRPR-expressing tumor cells. This allows for the specific delivery of a cytotoxic dose of alpha radiation to GRPR-expressing tumor cells. GRPR, also called bombesin receptor 2 (BB2), is a G protein-coupled seven-transmembrane receptor belonging to the bombesin receptor family. It is overexpressed in certain types of cancers.",
  "synonyms": [
    "212Pb-DOTAM-GRPR1",
    "Pb212-DOTAM-GRPR1"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lead-pb-212-dotam-grpr1/"
}